Alcohols and polyols

Organic compounds containing one or more hydroxyl functional groups bonded to a carbon atom; hydroxyls consist of an oxygen atom bonded to a hydrogen atom. Alcohols exist in chain, or as closed rings. Polyols contain two or more hydroxyl groups.

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1,561 – 1,575 of 6,680 results

1,561

Medchemexpress LLC Ladostigil hydrochlo 5mg | 209394-18-3 | 5MG

Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with IC50s of 37 1 and 31 8 M for MAO-B and AChE respectively Ladostigil hydrochloride exhibits neuroprotective antioxidant and anti-inflammatory activities Ladostigil can be used for the research of depression and Alzheimer s disease[1 [2 Ladostigil (hydrochloride) is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups

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1,562

Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 500 MG

SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. It inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis. This compound can be used for type 2 diabetes research.

Inhibits human TXNIP promoter activity and reduces TXNIP mRNA and protein levels in INS-1 cells.
Lowers glucagon secretion in TC1-6 cells and decreases glucagon secretion and action in vivo.
Reduces glucagon-induced glucose output from primary hepatocytes and blocks hepatic glucose output in vivo.
Reverses obesity- and Streptozotocin (STZ)-induced diabetes and hepatic steatosis in mice.
Orally bioavailable.
Well-tolerated in male C57BL/6J mice.

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1,563

Medchemexpress LLC Buspirone hydrochloride | 33386-08-2 | 99.99% | 1 ML

Buspirone hydrochloride is a 5-HT1A receptor agonist. It can be used for anxiety and depression research.

5-HT1A receptor agonist
Can be used for anxiety and depression research
Has cytotoxic effect in lymphocytes (0-400 μg/mL; 6 hours)
Induces ROS formation, MMP collapse, lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG) (0-180 μg/mL; 0-3 hours; lymphocytes)
Reduces anxiety/depression behaviors in C57BL/6N mice (1-5 mg/kg; i.p. and i.g.; for 5 days)
Restores IS-shifted β-diversity in the gut microbiota in C57BL/6N mice (1-5 mg/kg; i.p. and i.g.; for 5 days)
Reduces TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon in C57BL/6N mice
Reduces the IS- or EC-induced gut proteobacteria population in C57BL/6N mice

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1,564

Medchemexpress LLC Betaxolol hydrochloride | 63659-19-8 | 98.12% | 100 MG

Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma. It is a cardioselective beta-adrenergic receptor blocking agent. It has been shown to diminish anxiety-like behavior during early withdrawal from chronic cocaine administration in rats, and it produces less systemic beta 2- and possibly beta 1-adrenergic receptor blockade than either timolol or levobunolol, potentially making it safer for patients with reactive airway disease.

Selective beta1 adrenergic receptor blocker
Used in research for hypertension and glaucoma
Cardioselective beta-adrenergic receptor blocking agent
Diminishes anxiety-like behavior during withdrawal from chronic cocaine administration in rats
Produces less systemic beta 2- and possibly beta 1-adrenergic receptor blockade

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1,565

Medchemexpress LLC Aptiganel hydrochloride | 137160-11-3 | 99.9% | 339.86 | 25 MG

Aptiganel hydrochloride (Cerestat) is a non-competitive NMDA receptor antagonist with a neuroprotective effect. This product is for research use only.

Acts as a non-competitive NMDA receptor antagonist.
Exhibits neuroprotective properties.
Intended for research use only.

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1,566

Medchemexpress LLC Lidocaine hydrochloride hydrate | 6108-05-0 | 99.8% | 50 MG

Lidocaine hydrochloride hydrate is a sodium channel blocker that inhibits sodium channels with complex voltage and use dependence. It decreases the growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and inactivating the MEK/ERK and NF-κB signaling pathways. This amide derivative shows potential for research into ventricular arrhythmia.

Inhibits sodium channels
Decreases growth, migration, and invasion of gastric carcinoma cells
Upregulates miR-145 expression
Inactivates MEK/ERK and NF-κB signaling pathways
Decreases cell proliferation and viability in MKN45 cells
Increases apoptotic cell rate in MKN45 cells
Down-regulates Cyclin D1 and up-regulates p21 expression in MKN45 cells

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1,567

Medchemexpress LLC SRI-011381 hydrochloride | 2070014-88-7 | 99.6% | 365.94 g·mol⁻¹ | C20H32ClN3O | 1 ML

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist reported to exhibit neuroprotective effects. It is supplied for research use as a high-purity solid and as a 10 mM solution in DMSO suitable for in vitro and preclinical studies.

Orally active TGF-β signaling agonist.
Reported to exhibit neuroprotective effects.
Supplied as solid and as a 10 mM solution in DMSO.
High purity (99.55%).
Available in multiple small and bulk quantities.
For research use only; not for human consumption.

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1,568

Medchemexpress LLC SB 271046 Hydrochloride | 209481-24-3 | 99.9% | C20H23Cl2N3O3S2 | 50 MG

SB 271046 Hydrochloride is a potent, selective, orally active, and BBB-permeable 5-HT6 receptor antagonist. It exhibits high selectivity for the 5-HT6 receptor compared to 55 other receptors, binding sites, and ion channels, and also demonstrates anticonvulsant activity.

Potent, selective, orally active, and BBB-permeable 5-HT6 receptor antagonist
Over 200-fold selectivity for the 5-HT6 receptor
Shows anticonvulsant activity (EC50=0.16 μM)
Antagonizes 5-HT-induced stimulation of adenylyl cyclase activity (pA2=8.71)
Increases seizure threshold in rat maximal electroshock seizure threshold (MEST) test in vivo

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1,569

Medchemexpress LLC BMY 14802 hydrochloride | 105565-55-7 | MFCD04039786 | 98.0% | 384.85 | C18H23ClF2N4O | 5 MG

BMY-14802 hydrochloride is the hydrochloride salt of a selective and orally active sigma receptor antagonist that also exhibits 5-HT1A agonist and α1-adrenergic activity. It is used in preclinical research exploring antipsychotic effects and movement disorders, and is supplied for research use only.

Selective sigma receptor antagonist with reported IC50 = 112 nM.
Also displays 5-HT1A agonist activity and α1-adrenergic effects.
Supplied for research use only; not for human or veterinary use.
High purity by HPLC (≈98.0%).
Available as solid and as a 10 mM solution in DMSO.
Molecular weight 384.85; formula C18H23ClF2N4O.

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1,570

Medchemexpress LLC CHK1-IN-4 hydrochloride | 00-00-0 | 480.75 g/mol | C18H19BrClN7O2 | 5 MG

CHK1-IN-4 hydrochloride is the hydrochloride salt of a small-molecule inhibitor of checkpoint kinase 1 (CHK1). It is used in preclinical biochemical and cell-based studies to inhibit CHK1 phosphorylation and evaluate antitumor activity. Supplied as a solid with defined solubility and storage recommendations for research use.

Potent checkpoint kinase 1 (CHK1) inhibitor active in tumor cells.
Hydrochloride salt form for improved solubility and handling.
Solid material; soluble in DMSO at 5 mg/mL with ultrasonic and warming.
Storage: in solvent -80°C for up to 6 months; sealed -20°C for up to 1 month.
Supplied in small research pack sizes suitable for preclinical studies.

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1,571

Medchemexpress LLC Gefitinib hydrochloride | 184475-55-6 | 99.8% | 500 MG

Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective, and orally active inhibitor of EGFR tyrosine kinase, with an IC50 of 33 nM. It specifically inhibits EGF-stimulated tumor cell growth with an IC50 of 54 nM and blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Additionally, Gefitinib hydrochloride has been shown to induce autophagy and possesses antitumour activity.

Potent, selective, and orally active EGFR tyrosine kinase inhibitor.
Inhibits EGF-stimulated tumor cell growth.
Blocks EGF-stimulated EGFR autophosphorylation in tumor cells.
Induces autophagy.
Demonstrates antitumour activity.

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1,572

Medchemexpress LLC Olprinone hydrochloride | 119615-63-3 | 99.9% | C14H11ClN4O | 50 MG

Olprinone Hydrochloride is a potent phosphodiesterase (PDE) 3 inhibitor, showing IC50s of 0.35 μM for PDE3. It is utilized in research for heart failure due to its positive inotropic and vasodilative effects, and also demonstrates anti-inflammatory activity.

Potent PDE3 inhibitor
Used in research for heart failure
Exhibits positive inotropic and vasodilative effects
Demonstrates anti-inflammatory activity
Modulates inflammation associated with myocardial ischemia-reperfusion injury
Reduces pro-inflammatory cytokines such as TNF-α and IL-1β
Decreases expression of adhesion molecules like ICAM-1 and P-Selectin
Inhibits apoptosis related to myocardial injury

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1,573

Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | 99.5% | 576.13 g·mol⁻¹ | C28H42ClN7O4 | 10 MG

EPZ004777 hydrochloride is a potent, selective inhibitor of the histone methyltransferase DOT1L used in epigenetic and leukemia research. It inhibits DOT1L with an IC50 of 0.4 nM, reduces H3K79 methylation in cells, and has been used to selectively kill MLL-rearranged leukemia cells. This material is supplied for research use only.

Potent DOT1L inhibition (IC50 0.4 nM).
Selective activity in biochemical and cellular assays.
Reduces H3K79 methylation and downregulates leukemogenic gene expression.
High chemical purity (99.5%).
Available as solid and as DMSO solution for flexible use in experiments.
CAS number 1380316-03-9; molecular weight 576.13 g·mol⁻¹.

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1,574

Medchemexpress LLC Dyclonine hydrochloride | 536-43-6 | 99.3% | 1 ML

Dyclonine hydrochloride, also known as Dyclocaine hydrochloride, is an orally effective covalent inhibitor of Aldehyde Dehydrogenase (ALDH) that can cross the blood-brain barrier. It demonstrates sensitizing activities for targeted cancer cells and exhibits antibacterial properties. Additionally, Dyclonine hydrochloride functions as a local anesthetic, capable of suppressing or relieving pain by blocking the transmission of nerve impulses and inhibiting the sensation of touch and pain.

Orally effective ALDH covalent inhibitor
Crosses the blood-brain barrier
IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1
Sensitizes targeted cancer cells
Possesses antibacterial activity
Acts as a local anesthetic to suppress and relieve pain
Blocks the transmission of nerve impulses
Inhibits the sensation of touch and pain

Pricing & Availability

1,575

Medchemexpress LLC Midodrine hydrochloride | 43218-56-0 | 99.9% | 10 MG

Midodrine hydrochloride is a selective and orally active adrenergic α1-receptor agonist. It strengthens vascular contraction and is utilized in research concerning cardiovascular diseases, such as orthostatic hypotension.

Selective and orally active adrenergic α1-receptor agonist
Strengthens vascular contraction
Utilized in research for cardiovascular diseases like orthostatic hypotension
Increases p-AMPK and PPARδ expression
Increases Ca2+ in C2C12, HL1 and HepG2 cells
Increases maximal mitochondrial oxidative phosphorylation and ATP content in C2C12 cells
Reduces cellular lipid content in 3T3-L1 cells
Reduces platelet-activating factor-induced death in mice
Shows anti-hypotensive effects in orthostatic hypotension rat models
Relieves hypertension in spontaneously hypertensive rat models

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Alcohols and polyols

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Medchemexpress LLC Ladostigil hydrochlo 5mg | 209394-18-3 | 5MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Buspirone hydrochloride | 33386-08-2 | 99.99% | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Betaxolol hydrochloride | 63659-19-8 | 98.12% | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Aptiganel hydrochloride | 137160-11-3 | 99.9% | 339.86 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Lidocaine hydrochloride hydrate | 6108-05-0 | 99.8% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SRI-011381 hydrochloride | 2070014-88-7 | 99.6% | 365.94 g·mol⁻¹ | C20H32ClN3O | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SB 271046 Hydrochloride | 209481-24-3 | 99.9% | C20H23Cl2N3O3S2 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC BMY 14802 hydrochloride | 105565-55-7 | MFCD04039786 | 98.0% | 384.85 | C18H23ClF2N4O | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC CHK1-IN-4 hydrochloride | 00-00-0 | 480.75 g/mol | C18H19BrClN7O2 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Gefitinib hydrochloride | 184475-55-6 | 99.8% | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Olprinone hydrochloride | 119615-63-3 | 99.9% | C14H11ClN4O | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | 99.5% | 576.13 g·mol⁻¹ | C28H42ClN7O4 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Dyclonine hydrochloride | 536-43-6 | 99.3% | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Midodrine hydrochloride | 43218-56-0 | 99.9% | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More